A healthier form of salt could prevent millions of deaths from stroke and heart disease

by George Institute for Global Health

edited by Gaby Clark, reviewed by Robert Egan

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Researchers from The George Institute for Global Health assessed the health benefits of switching the salt supply to potassium-enriched salt across 193 countries. They found almost 3 million deaths and 10 million new cases of cardiovascular and kidney disease could be prevented globally each year. The research is published in Nature Health.

Bruce Neal, senior professorial fellow at The George Institute, said the health gains would be widespread and could avert as many as one in 10 cardiovascular deaths in most countries.

"Consuming too much sodium and not enough potassium are well-established causes of high blood pressure—a major risk factor for life-threatening conditions like strokes, heart attacks and kidney disease. Switching to potassium-enriched salt addresses both these dietary issues at the same time, with substantial health benefits," he said.

"While a global shift from regular salt to a potassium-enriched substitute is aspirational, this is a starting point to get countries thinking about the opportunity—with much greater potential and at much lower cost than many drug-based treatments."

Replacing sodium with potassium

Potassium-enriched salt is made by replacing some of the sodium chloride—which makes up regular table salt—with potassium chloride. It looks, tastes and cooks like regular salt. In 2025, the World Health Organization (WHO) endorsed the use of potassium-enriched salt to reduce blood pressure and the risk of cardiovascular disease.

Worldwide, one in three adults aged 30–79 have high blood pressure (hypertension), equivalent to around 1.4 billion people. Cardiovascular disease (CVD) is the leading cause of death and disability globally, causing 19.2 million deaths in 2023, an increase of nearly 50% over the last 30 years.

The study examined a range of hypothetical scenarios, from a full global switch of all salt to more targeted use among people with diagnosed and treated high blood pressure. Even the most limited level of switching still showed major health gains.

Managing risks in kidney disease

While the potential benefits are large, one concern is the risk of high potassium levels (hyperkalemia) in people with advanced kidney disease. The study found, however, that even among patients with advanced kidney disease the benefits outweighed the risks.

"People with serious kidney disease and those taking medications that significantly raise blood potassium levels need to take precautions. Risks for this group can be managed effectively through patient education, product labeling and clinical oversight," said nephrologist Vivek Jha, senior professorial fellow at The George Institute in India.

Bringing the food industry on board

Neal highlighted the need for country-specific strategies, tailored to whether most sodium intake comes from household salt or processed foods.

"To realize the maximum benefits from switching to potassium-enriched salt, we need to see the food industry in Europe and North America—where over 70% of salt intake comes from processed and restaurant foods—get on board. This would also require investigating ways to scale up the production of potassium chloride to meet demand," he said.

Publication details

Global health outcomes from replacing dietary sodium chloride with potassium-enriched salt, Nature Health (2026). DOI: 10.1038/s44360-026-00216-9

Journal information: Nature Health

Key medical concepts

Cardiovascular DiseasesHigh Blood PressureHyperkalemia

Clinical categories

CardiologyNutrition & Healthy eatingNephrologyCommon illnesses & PreventionHealthy living Provided by George Institute for Global Health Who's behind this story?

Gaby Clark

MA in English, copy editor since 2021 with experience in higher education and health content. Dedicated to trustworthy science news. Full profile →

Robert Egan

Bachelor's in mathematical biology, Master's in creative writing. Well-traveled with unique perspectives on science and language. Full profile →

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