At least 7 dead after UPS plane crashes during takeoff at Louisville airport

A shelter-in-place order was issued for all locations within 5 miles of the airport.

A large UPS cargo plane crashed and exploded Tuesday while taking off from an airport in Louisville, Kentucky, leaving at least 7 people dead and 11 injured.

Video showed flames on the plane’s left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a huge fireball. Video also revealed portions of a building’s shredded roof next to the end of the runway.

Among the 11 who were hurt, some had “very significant” injuries, Kentucky Gov. Andy Beshear said.

“Anybody who has seen the images, the video, knows how violent this crash is,” he said.

Those numbers are expected to grow, the governor said. The plane crashed about 5:15 p.m. as it was departing for Honolulu from Louisville's Muhammad Ali International Airport, the Federal Aviation Administration said.

A shelter-in-place order has been issued for all locations within 5 miles of the airport and asks the public to avoid the area until further notice, Louisville Metro Emergency Services said.

Mayor Craig Greenberg told WLKY-TV that fuel on the plane was an “extreme reason for concern in so many different ways.”

Louisville Muhammad Ali International Airport announced on social media at 5:36 p.m. local time that the airfield was closed after “an aircraft incident."

UPS has a large presence in Louisville. UPS Air Operations is headquartered in the city, where it also has its main hub.

The FAA and National Transportation Safety Board will investigate, the FAA said.

This is breaking news. Check back for updates.