The state of US-Iran negotiations was in flux early on May 22, with the sides still at odds over future control of the Strait of Hormuz and Iran’s right to enrich uranium -- among other issues -- and with the Pakistani mediator heading to Tehran in the latest peace push.

Trump has 'other options' if talks fail, says Rubio, as US president vows to retrieve, possibly destroy Iran's highly enriched uranium; IDF chief says military 'on highest alert' over holiday