Walking performance and daily activity are linked to better quality of life in people with multiple sclerosis

by University of Eastern Finland

edited by Swati Mestri, reviewed by Robert Egan

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A study by the University of Eastern Finland found that quality of life in people with multiple sclerosis (MS) is strongly associated with walking performance and functional capacity.

The findings indicate that, among individuals with relapsing-remitting multiple sclerosis (RRMS), lower levels of disability, better walking performance and higher levels of daily physical activity are linked to better perceived quality of life. The results also suggest that simple walking tests may provide valuable insight into a patient's overall well-being and could help support a more active lifestyle as part of MS care.

The study is published in the journal Multiple Sclerosis and Related Disorders.

Multiple sclerosis has a significant impact on patients' quality of life. The study investigated associations between quality of life, accelerometer-measured physical activity, walking performance and functional capacity in people with RRMS.

The researchers used a broad range of measurement methods. Physical activity was objectively assessed using an accelerometer, quality of life was evaluated with two established questionnaires (15D and RAND-36), and disability was measured using the EDSS and MSFC scales. In addition, participants completed several physical performance assessments, including the six-minute walk test.

People with RRMS reported significantly lower quality of life than healthy controls. Greater disability was strongly associated with poorer quality of life, while better walking performance and a higher daily step count were linked to better well-being. In contrast, the intensity of physical activity was not associated with quality of life.

Multiple sclerosis can significantly affect everyday life and overall well-being. The burden of the disease, combined with its unpredictable course, often leads to a reduced quality of life.

"These findings reinforce previous research and highlight the potential benefits of maintaining an active lifestyle. The results may help health care professionals encourage people with MS to increase their daily activity levels to support better quality of life," said doctoral researcher Marko Luostarinen from the University of Eastern Finland.

Publication details

Marko Luostarinen et al, Walking performance is associated with quality of life and disability in relapsing–remitting multiple sclerosis, Multiple Sclerosis and Related Disorders (2026). DOI: 10.1016/j.msard.2026.107875

Journal information: Multiple Sclerosis and Related Disorders

Key medical concepts

Multiple Sclerosis, Relapsing-RemittingQuality of LifeDisability type

Clinical categories

NeurologyFitness & Physical activityPsychology & Mental health Provided by University of Eastern Finland Who's behind this story?

Swati Mestri

Swati Mestri holds a bachelor's degree in Electronics Engineering and has worked as a content editor since 2019. She has experience editing research documents across technology, health care, and materials science, and has a particular interest in technology and space. Full profile →

Robert Egan

Bachelor's in mathematical biology, Master's in creative writing. Well-traveled with unique perspectives on science and language. Full profile →

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