Edaravone shows promise in targeting brain tumor stem cells

In an effort to rapidly identify new treatments effective against BTSCs, a team of researchers from the University of Ottawa, Canada, tested Edaravone, an FDA-approved drug, for its efficacy against BTSCs, knowing that Edaravone blocks cellular processes which are important for the growth and survival of BTSCs. Indeed, in cell cultures in the lab, Edaravone inhibited BTSC growth at low concentrations and caused cell death at higher concentrations, whereas normal brain stem cells were relatively unaffected. Encouragingly, brain tumor growth was delayed in mice receiving Edaravone and the treatment prolonged their survival. This effect was even more pronounced when Edaravone was combined with irradiation therapy. Since Edaravone has already received FDA clearance for other conditions, this drug could potentially be repurposed for treating glioblastoma in a shorter timeframe. However, additional pre-clinical and clinical studies will first have to confirm that Edaravone is a safe and effective drug against glioblastomas. This results were published today in Stem Cell Reports.

Source:

International Society for Stem Cell Research

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