A US Airman prepares an A-10 Thunderbolt II for flight from a base in the US Central Command area of responsibility, December 19, 2025, in support of Operation Hawkeye Strike against Islamic State targets in Syria. (US Air Force/DVIDS via AP)
Hegseth: 'It is a declaration of vengeance'

US launches ‘large-scale’ operation against ISIS in Syria after deadly attack on Americans

Over 70 targets hit in Operation Hawkeye Strike, which Trump calls a ‘very serious retaliation’; Israel reportedly given heads up ahead of airstrikes

by · The Times of Israel

WASHINGTON — The Trump administration launched military strikes Friday in Syria to “eliminate” Islamic State group fighters and weapons sites in retaliation for an ambush attack that killed two US troops and an American civilian interpreter almost a week ago.

A US official described it as “a large-scale” strike that hit 70 targets in areas across central Syria that had IS infrastructure and weapons. Another US official, who also spoke on condition of anonymity to discuss sensitive operations, said more strikes should be expected.

“This is not the beginning of a war — it is a declaration of vengeance. The United States of America, under President Trump’s leadership, will never hesitate and never relent to defend our people,” Defense Secretary Pete Hegseth said on social media.

Israel was updated ahead of US strikes on Islamic State targets in Syria, a senior US official told the Walla news site.

The new military operation in Syria comes even as the Trump administration has said it’s looking to focus closer to home in the Western Hemisphere, building up an armada in the Caribbean Sea as it targets alleged drug-smuggling boats and vowing to keep seizing sanctioned oil tankers as part of a pressure campaign on Venezuela’s leader.

The US has shifted significant resources away from the Middle East to further those goals: Its most advanced aircraft carrier arrived in South American waters last month from the Mediterranean Sea.

Trump vowed retaliation

US President Donald Trump pledged “very serious retaliation” after the shooting in the Syrian desert, for which he blamed IS. Those killed were among hundreds of US troops deployed in eastern Syria as part of a coalition fighting the militant group.

During a speech in North Carolina on Friday evening, the president hailed the operation as a “massive strike” that took out the “ISIS thugs in Syria who were trying to regroup.”

US President Donald Trump finishes his remarks at the Rocky Mount Events Center in Rocky Mount, North Carolina, Dec. 19, 2025. (AP Photo/Karl B DeBlaker)

Earlier, in his social media post, he reiterated his backing for Syrian President Ahmed al-Sharaa, who Trump said was “fully in support” of the US effort.

Trump also offered an all-caps threat, warning ISIS against attacking American personnel again.

“All terrorists who are evil enough to attack Americans are hereby warned — YOU WILL BE HIT HARDER THAN YOU HAVE EVER BEEN HIT BEFORE IF YOU, IN ANY WAY, ATTACK OR THREATEN THE U.S.A.,” the president added.

The attack was conducted using F-15 Eagle jets, A-10 Thunderbolt ground attack aircraft, and AH-64 Apache helicopters, the US officials said. F-16 fighter jets from Jordan and HIMARS rocket artillery were also used, one official added.

US Central Command, which oversees the region, said in a social media post that American jets, helicopters, and artillery employed more than 100 precision munitions on Syrian targets.

How Syria has responded

The attack was a major test for the warming ties between the United States and Syria since the ouster of autocratic leader Bashar al-Assad a year ago.

Trump has stressed that Syria was fighting alongside US troops and said Sharaa was “extremely angry and disturbed by this attack,” which came as the US military is expanding its cooperation with Syrian security forces.

A US Army AH-64 Apache Attack Helicopter prepares to support Operation Hawkeye Strike against Islamic State targets in Syria, in the US Central Command area of responsibility, December 19, 2025. (US AIR FORCE / AFP)

Syria’s foreign ministry in a statement on X following the launch of US strikes said that last week’s attack “underscores the urgent necessity of strengthening international cooperation to combat terrorism in all its forms” and that Syria is committed “to fighting ISIS and ensuring that it has no safe havens on Syrian territory and will continue to intensify military operations against it wherever it poses a threat.”

Syrian state television reported that the US strikes hit targets in rural areas of Deir ez-Zor and Raqqa provinces and in the Jabal al-Amour area near the historic city of Palmyra. It said they targeted “weapons storage sites and headquarters used by ISIS as launching points for its operations in the region.”

ISIS has not said it carried out the attack on the US service members, but the group has claimed responsibility for two attacks on Syrian security forces since, one of which killed four Syrian soldiers in Idlib province. The group in its statements described Sharaa’s government and army as “apostates.” While Sharaa once led a group affiliated with al-Qaida, he has had a long-running enmity with ISIS.

The Americans who were killed

Trump this week met privately with the families of the slain Americans at Dover Air Force Base in Delaware before he joined top military officials and other dignitaries on the tarmac for the dignified transfer, a solemn and largely silent ritual honoring US service members killed in action.

An Army carry team moves the flag-draped transfer case with the remains of civilian interpreter Ayad Mansoor Sakat from a C-17 aircraft during a casualty return, December 17, 2025, at Dover Air Force Base, Delaware. (AP Photo/Evan Vucci)

The guardsmen killed in Syria last Saturday were Sgt. Edgar Brian Torres-Tovar, 25, of Des Moines, and Sgt. William Nathaniel Howard, 29, of Marshalltown. Ayad Mansoor Sakat, of Macomb, Michigan, a US civilian working as an interpreter, was also killed.

The shooting near Palmyra also wounded three other US troops as well as members of Syria’s security forces, and the gunman was killed. The assailant had joined Syria’s internal security forces as a base security guard two months ago and was recently reassigned because of suspicions that he might be affiliated with ISIS, Interior Ministry spokesperson Nour al-Din al-Baba has said.

The man stormed a meeting between US and Syrian security officials who were having lunch together and opened fire after clashing with Syrian guards.

Times of Israel staff contributed to this report.