National Basketball Association

2025-26 NBA Playoff Odds: Spreads, Lines for Second-Round Series

03 May 2026, 02:12 · FOX Sports

Now the NBA playoffs are in the swing of things.

Let's check out the odds for the second round of the playoffs, at DraftKings Sportsbook as of May 5.

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EAST SECOND ROUND

No. 4 CLEVELAND (+105) vs. No. 1 DETROIT (-125)
Season series: Tied 2-2

GAME 1 — CLE @ DET (May 5)

Spread: Pistons -3.5
Moneyline: Pistons -148, Cavs +124
O/U: 215.5

What to know: Both of these higher seeds survived Game 7s in the first round, and now, it appears another slugfest is in store. Consider this: Despite splitting the regular-season series, the final three games between these two were decided by a combined 11 points. In addition, one of those games went to overtime, and they both also won on the others' home court. That's how close this one will be. One question at the top of every Cleveland fan's mind has to be how will the Cavs deal with Pistons All-Star Cade Cunningham? He averaged 32.4 points and 7.1 assists per game in the first round, including games of 45, 39 and 32 (twice).

No. 7 PHILADELPHIA (+350) vs. No. 3 NEW YORK (-450)
NYK leads 1-0

GAME 2 — PHI @ NYK (May 6)

Spread: Knicks -6.5
Moneyline: Knicks -270, 76ers +220
O/U: 214.5

What to know: Game 1 was all New York, all the time. The Knicks led by eight after the first quarter, 23 at half, 31 at the end of the third and ended the night with a 39-point victory. Jalen Brunson led the way, scoring 35 on 12-for-18 shooting, and as a team, the Knicks shot 63% from the field and 51% from 3. That'll get it done in the playoffs. Can N.Y. keep up its hot shooting in Game 2?

WEST SECOND ROUND

No. 4 LOS ANGELES (+900) vs. No. 1 OKLAHOMA CITY (-1600)
Season series: OKC wins 4-0

GAME 1 — LAL @ OKC (May 5)

Spread: Thunder -15.5
Moneyline: Thunder -1100, Lakers +700
O/U: 213.5

What to know: DraftKings has the Thunder at +120 (shortest ‘Correct score’ odds) to sweep the Lakers in the postseason just like they did in the regular season. Why? Well, maybe because in those four regular-season wins, OKC beat L.A. by an average margin of 29.3 points per game, including a 43-point win and a 36-point win. Add to that equation the fact that Luka Dončić has still not returned from injury for Los Angeles, and we could be staring at a second playoff sweep for the defending champions.

No. 6 MINNESOTA (+160) vs. No. 3 SAN ANTONIO (-190)
MIN leads 1-0

GAME 2 — MIN @ SAS (May 6)

Spread: Spurs -9.5
Moneyline: Spurs -410, Wolves +320
O/U: 215.5

What to know: These Timberwolves are a force to be reckoned with. They went into San Antonio and won a Game 1 nail-biter, after Anthony Edwards returned from a recent knee injury way earlier than expected. He scored 18 points in 25 minutes off the bench. As for San Antonio, its star, Victor Wembanyama, managed a triple-double, but it wasn't a pretty one. He had 15 rebounds and an astounding 12 blocks, but he coupled it with just 11 points on 5-for-17 shooting, including 0-for-8 from 3. The Wolves are rough and tough and can defend with the best of 'em, having held their opponents to 102 points or fewer in four of their seven playoff games this season.

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