Self-learning AI reveals NFL against the spread, over-under, money-line picks for each 2024 Week 3 game

SportsLine AI reveals its NFL predictions and NFL betting picks for all 16 NFL games in Week 3

The Chiefs have avoided a Super Bowl hangover so far, picking up wins over the Ravens and Bengals to open the season. They will go on the road for the first time against Atlanta on Sunday Night Football during the Week 3 NFL schedule. The Falcons opened the season with a loss to the Steelers, but bounced back with an impressive comeback win at Philadelphia last week. Kansas City is a 3.5-point road favorite in the Week 3 NFL odds, while the total for that game has dropped from 50 to 46.5. There are four more NFL road favorites in the Week 3 NFL spreads, including Detroit (-3) at Arizona and Houston (-2.5) at Minnesota.

Detroit is hitting the road for the first time as well following a 20-16 loss against Tampa Bay last week. The Lions have covered the spread in seven of their last nine games dating back to last season, so should you back them with your Week 3 NFL betting picks? Before you make any Week 3 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 3, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 3 NFL schedule here.

Top Week 3 NFL AI picks

After analyzing every game in Week 3, the AI PickBot says the Rams cover as seven-point home underdogs against the 49ers. Injuries are at the forefront of this NFC West showdown, as the Rams will be playing without wide receivers Cooper Kupp (ankle) and Puka Nacua (knee). San Francisco has major injury issues of its own, with running back Christian McCaffrey (Achilles) and wide receiver Deebo Samuel (calf) both sidelined.

The 49ers relied heavily on Samuel in their 23-17 loss to Minnesota last week, as he caught eight passes for 110 yards. His absence is not going to help a team that has failed to cover the spread in five of its last six games, especially since Los Angeles is 5-1 in its last six home games. The Rams have been a profitable side to back, covering in seven of their last 10 games, and the AI PickBot has the Rams listed as an A-rated spread pick. See its other Week 3 football predictions and football picks at SportsLine.

How to make Week 3 NFL picks

In addition, the AI PickBot has generated five other A-rated picks for Week 3. You need to see the AI PickBot's picks before making any Week 3 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 3 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.