The Brazilian international will be unavailable for selection against Aston Villa after receiving his fifth individual yellow card this season in United's clash with Bournemouth. This means Casemiro will serve a one-match suspension. He has been one of Amorim's go-to men this campaign after facing questions regarding his future at the club over the summer. (Image: (Photo by Robbie Jay Barratt - AMA/Getty Images)) 1 of 8
Harry Maguire is still recovering from an injury he sustained in Man United's 2-2 draw with Tottenham earlier this season. The English defender has suffered a supposed thigh injury which could see him sidelined until late December. The former Red's skipper has been rotated in and out of the squad since the start of the season. (Image: (Photo by Michael Zemanek/Shutterstock)) 2 of 8
The 26-year-old centre-back will not be available against Villa as he remains out of the squad due to a back injury he endured in late November. Amorim had stated earlier this month that he was being "careful" with De Ligt in not returning him to the pitch too quickly. Before his back problem, the Dutchman had started all 13 available games in the league. 3 of 8
Ruben Amorim will also be without three further players due to their participation in the Africa Cup of Nations. Bryan Mbeumo Noussair Mazraoui Amad Diallo (Image: SmartFrame/SportImage) 4 of 8